2013
Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, Asano M, Shibamoto T, Takuwa Y. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. J Allergy Clin Immunol. 2013 Nov;132(5):1205-1214.e9. doi: 10.1016/j.jaci.2013.07.026. Epub 2013 Sep 8. PMID: 24021572 [PubMed - in process]
Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T.CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Clin Exp Nephrol. 2013 Apr 6. [Epub ahead of print] PMID: 23564379 [PubMed - as supplied by publisher]
2012
Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa Y. Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J Biol Chem. 2013 Jan 25;288(4):2325-39. doi: 10.1074/jbc.M112.409656. Epub 2012 Nov 28. PMID: 23192342 [PubMed - indexed for MEDLINE]
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med. 2012 Oct;18(10):1560-9. doi: 10.1038/nm.2928. Epub 2012 Sep 16. PMID: 22983395 [PubMed - indexed for MEDLINE]
Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y, Meikle PJ, Pitson SM, Febbraio MA. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6. PMID: 22961081 [PubMed - indexed for MEDLINE]
Takuwa Y, Ikeda H, Okamoto Y, Takuwa N, Yoshioka K. Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases. Biochim Biophys Acta. 2013 Jan;1831(1):185-92. doi: 10.1016/j.bbalip.2012.06.008. Epub 2012 Jun 23. Review. PMID: 22735357 [PubMed - indexed for MEDLINE]
Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. Sphingosine-1-phosphate signaling in physiology and diseases. Biofactors. 2012 Sep-Oct;38(5):329-37. doi: 10.1002/biof.1030. Epub 2012 Jun 7. Review. PMID: 22674845 [PubMed - indexed for MEDLINE]
Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y. Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. Hepatology. 2012 Oct;56(4):1427-38. doi: 10.1002/hep.25780. PMID: 22505286 [PubMed - indexed for MEDLINE]
2011
Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K, Takuwa Y. Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde. Am J Cancer Res. 2011;1(4):460-81. Epub 2011 Feb 16. PMID: 21984966 [PubMed]
Okamoto Y, Yoshioka K, Takuwa N, Takuwa Y. [Cardiovascular function of sphingosine 1-phosphate signaling]. Seikagaku. 2011 Jun;83(6):536-44. Review. Japanese. No abstract available. PMID: 21800684 [PubMed - indexed for MEDLINE]
Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y. Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells. J Atheroscler Thromb. 2011;18(9):762-73. Epub 2011 Jun 1. PMID: 21628952 [PubMed - indexed for MEDLINE]
2010
Seok YM, Azam MA, Okamoto Y, Sato A, Yoshioka K, Maeda M, Kim IK, Takuw Y. Enhanced Ca2+-Dependent Activation of PI3KC2 alpha Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats. Hypertension 56(5):934-941. 2010
H Suzuki, H Hashimoto, M Kawasaki, M Watanabe, H Otsubo, T Ishikura, H Fujihara, H Ohnishi, E Onuma, H Yamada-Okabe, Y Takuwa, E Ogata, T Nakamura, Y Ueta. Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-,LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats. Int J Cancer. 2010 In press.
H Ohkawara, T Ishibashi, S Saitoh, N Inoue, K Sugimoto, M Kamioka, H Uekita, T Kaneshiro, K Ando, Y Takuwa, Y Maruyama, Y Takeishi. Preventive effects of pravastatin on thrombintriggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo. Cardiovasc. Res. 2010 In press.
Y Takuwa, W Du, X Qi, Y Okamoto, N Takuwa, K Yoshioka. Roles of sphingosine-1-phosphate signaling in angiogenesis. World J Biol Chem. 1(10):298-306, 2010
Y. Yoshida, M. Nakada, N. Sugimoto, T. Harada, Y. Hayashi, D. Kita, N. Uchiyama, Y. Hayashi, A. Yachie, Y. Takuwa, JI. Hamada. Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma. Int J Cancer. 126(10):2341-2352. 2010
Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Eur J Pharmacol. 2010 May 25;634(1-3):121-31.
Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y. S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Research 2010;70: 772 -781
N. Takuwa, S. Ohkura, S. Takashima, K. Ohtani, Y. Okamoto, T. Tanaka, K, Hirano, S. Usui, F. Wang, W. Du, K. Yoshioka, Y. Banno, M. Sasaki, I. Ichi, M. Okamura, N. Sugimoto, K. Mizugishi, Y. Nakanuma, I. Ishii, M. Takamura, S. Kaneko, S. Kojo, K. Satouchi, K.
Mitumori, J. Chun, Y. Takuwa S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res 85(3):484-93. 2010
2009
Y. Takuwa, K. shioka, Y. Okamoto , N. Takuwa The role of class II PI 3-kinase signaling
pathway in physiology and diseases. Curr Biodata Targeted Proteins Database. In press.
Bloggs, J. (2009) The Role of Class II PI 3-kinase Signaling in Physiology and Disease
Targeted Proteins Database 1, [22910], 10.2970/tpdb.2009.246.
A. Shiratsuchi, M. Ichiki, Y. Okamoto, N. Ueda, N. Sugimoto, Y. Takuwa, Y. Nakanishi
Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis
through inhibition of Rac1 and Cdc42 J. Biochem. 145(1)43-50, 2009
K. Yonesu, Y. Kawase, T. Inoue , N. Takagi, J. Tsuchida, Y. Takuwa, S. Kumakura, F. Nara.
Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis: Analyses using a new
S1P(1) antagonist of non-sphingosine-1-phosphate analog. Biochem Pharmacol.
15;77(6):1011-1020. 2009
K. Sugimoto, T. Ishibashi, T. Sawamura, N. Inoue, M. Kamioka, H. Uekita, H. Ohkawara, T.
Sakamoto, N. Sakamoto, Y. Okamoto, Y. Takuwa, A. Kakino, Y. Fujita, T. Tanaka, T.
Teramoto, Y. Maruyama, Y. Takeishi LOX-1-LOX-1-MT1-MMP axis is crucial for RhoA and Rac1
activation induced by oxidized low-d nsity lipoprotein in endothelial cells Cardiovasc
Res. 84(1):127-36. 2009
H. Zhong, O. Matsui, K. Xu, T. Ogi, J. Sanada, Y. Okamoto, Y. Tabata, Y. Takuwa. Gene
transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated
polyester stent-graft. J Vasc Surg 50(6):1433-43. 2009
Y. Yoshida, M. Nakada, N. Sugimoto, T. Harada, Y. Hayashi, D. Kita, N. Uchiyama, Y.
Hayashi, A. Yachie, Y. Takuwa, JI. Hamada Sphingosine-1-phosphate receptor type 1
regulates glioma cell proliferation and correlates with survival of patients with
glioblastoma. Int J Cancer 2009 in press
W Du, N Takuwa, K Yoshioka, Y Okamoto, K Gonda, K Sugihara, A Fukamizu, M Asano, Y Takuwa
S1P2, the G protein-coupled receptor for sphingosine-1-phosphate,negatively regulates
tumor angiogenesis and tumor growth in vivo in mice. 2009 Cancer Res In press.
2008
O. Oyama, N. Sugimoto, X. Qi, N. Takuwa, K. Mizugishi, J. Koizumi, Y. Takuwa. The
lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in
ischemic hindlimbs of mice. Cardiovasc Res. 78. 301-307, 2008
Y. Takuwa, Y. Okamoto, K. Yoshioka, N. Takuwa Sphingosine-1-phosphatesignaling and
biological activitiesin the cardiovascular system. Biochim. Biophys. Acta 1781(9):483-488,2008
S. Takashima, N. Sugimoto, N. Takuwa, Y. Okamoto, K. Yoshioka, M. Takamura, S. Takata, S.
Kanekob and Y. Takuwa. G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration
in vascular smooth muscle in a manner dependenton Rho but not Rho kinase. Cardiovasc Res
79(4):689-697,2008
M. Takabatake, T. Takuwa, N.Takuw, H.Yasuno, S. Matsumoto, M. Shibutani, K. Mitsumori. A
case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor
deficient mouse. J Vet Med Sci. 70(5): 483-485, 2008
2007
T. Nakamura, K. Yonesu, Y. Mizuno, C. Suzuki, Y. Sakata, Y. Takuwa, F. Nara, S. Satoh, Synthesis and SAR studies of a novel class of S1P(1) receptor antagonists. Bioorg Med Chem. 2007 Mar 3; [In print][PubMed]
K.
Yoshioka, N. Sugimoto, N. Takuwa, Y. Takuwa, Essential role
for class II phosphoinositide 3-kinase alpha-isoform in
Ca2+-induced, Rho- and Rho kinase-dependent regulation of
myosin phosphatase and contraction in isolated vascular
smooth muscle cells. Mol Pharmacol.
2007;71(3):912-920.[PubMed]
H. Hashimoto, Y. Azuma, M. Kawasaki, H. Fujihara, E .Onuma,
H. Yamada-Okabe, Y. Takuwa, E. Ogata, and Y. Ueta,
Parathyroid Hormone-Related Protein Induces Cachectic
Syndromes without Directly Modulating the Expression of
Hypothalamic Feeding-Regulating Peptides. Clin Cancer Res
2007;13: 292-298.[PubMed]
Sakamoto
T, Ishibashi T, Sugimoto K, Sakamoto N, Ohkawara H, Niinuma
M, Nagata K, Kamioka M, Sugimoto N, Watanabe A, Kurabayashi
M, Takuwa Y, Maruyama Y. RhoA-dependent PAI-1 gene
expression induced in endothelial cells by monocyte
adhesion mediates geranylgeranyl transferase I and Ca2+
signaling. Atherosclerosis. 2007 ;193(1):44-54.
Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa
K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y,
Kawada T, Brownlee M, Nishikawa T, Araki E. Statins
activate peroxisome proliferator-activated receptor gamma
through extracellular signal-regulated kinase 1/2 and p38
mitogen-activated protein kinase-dependent cyclooxygenase-2
expression in macrophages. Circ Res. 2007;
100(10):1442-1451.
Ueta Y, Hashimoto H, Onuma E, Takuwa Y, Ogata E.
Hypothalamic Neuropeptides and Appetite Response in
Anorexia-Cachexia Animal. Endocr J. 2007;54(6):831-838
Oyama O, Sugimoto N, Qi X, Takuwa N, Mizugishi K, Koizumi
J, Takuwa Y. The lysophospholipid mediator
sphingosine-1-phosphate promotes angiogenesis in vivo in
ischemic hindlimbs of mice. Cardiovasc Res. 2008 inpress.
Masayoshi Takabayake, Yoh Takuwa, Noriko Takuwa, Hironobu
Yasuno, Sayaka Matsumoto, Makoto Sshibutani and Kunitoshi
Mitsumori, A Case report of a renal mixed epithelial and
stromal tumor in a heterozygous S1P2 receptor deficient
mouse. J. Veterinary Medical Sciences 2008 In press
2006
MA.
Azam, K. Yoshioka, S. Ohkura, N. Takuwa, N. Sugimoto, K.
Sato, Y. Takuwa, Ca2+-dependent, inhibitory effects of
cyclic adenosine 5'-monophosphate on Ca2+ regulation of
phosphoinositide 3-kinase C2a, Rho, and myosin phosphatase
in vascular smooth muscle. Mol Pharmacol.
2007;71(3):912-920.[PubMed]
I. Inoki, N. Takuwa, N. Sugimoto, K. Yoshioka, S. Takata,
S. Kaneko and Y. Takuwa, Negative regulation of endothelial
morphogenesis and angiogenesis by S1P2 receptor. Biochem.
Biophys. Res. Commun. 2006;346:293-300[PubMed]
Y. Wang, K. Yoshioka, MA. Azam, N. Takuwa, S. Sakurada, Y.
Kayaba, N. sugimoto, I. Inoki, T. Kimura, T. Kuwai and Y.
Takuwa, Class II phosphoinositide 3-kinase alfa-isoform
regulates Rho, myosin phosphatase and contraction in
vascular smooth muscle. Biochem J 2006; 394:
581-592[PubMed]
Y. Takuwa, N. Sugimoto, N.Takuwa, and Y. Igarasi, Signaling
mechanisms for positive and negative regulation of cell
motility by sphingosine-1-phosphate receptors. Sphingolipid
Biology. 2006; pp. 415-425 Y. Hirabayashi, Y. Igarashi,
A.H. Merrill(Eds.) Springer
Zheng
R, Iwase A, Shen R, Goodman OB, Sugimoto N, Takuwa Y,
Lerner DJ, Nanus DM., Neuropeptide-stimulated cell
migration in prostate cancer cells is mediated by RhoA
kinase signaling and inhibited by neutral
endopeptidase.Oncogene. 2006; 25(44), 5942-5952
[PubMed]
Tanabe A, Kamisuki Y, Hidaka H, Suzuki M, Negishi M, Takuwa
Y.
PKC phosphorylates MARCKS Ser159 not only directly but
also through RhoA/ROCK. Biochem Biophys Res Commun. 2006
Jun 23;345(1):156-61[PubMed]
Naotoshi Sugimoto, Noriko Takuwa, Kazuaki Yoshioka and Yoh
Takuwa Rho-dependent, Rho kinase-independent inhibitory
regulation of Rac and cell migration by
LPA1
receptor in Gi-inactivated
CHO sells. Exp. Cell Res. 2006; 312,
1899-1903[PubMed]
2005
T Maruko, T Nakahara, K Sakamoto, M Saito,N Sugimoto, Y
Takuwa and K Ishii Involvement of the subunits of G
proteins in the cAMP response induced by stimulation of the
histamine H1
receptor. Naunyn-Schmiedegerg's Arch Pharmacol
2005;372:153-159[PubMed]
T. Sakamoto, T. Ishibashi, N. Sakamoto, K. Sugimoto, K.
Egashira H. Ohkawara, K. Nagata, K. Yokoyama, M. Kamioka,
T. Ichiki, N. Sugimoto, M. Kurabayashi, K. Suzuki, Y.
Takuwa, and Y. Maruyama Endogenous NO Blockade Enhances
Tissue Factor Expression via Increased Ca2+ Influx through
MCP-1 in Endothelial Cells by Monocyte Adhesion.
Arterioscler Thromb Vasc Biol.
2005;25(9):2005-2011[PubMed]
H. Ohtsu, M. Mifune, G. D. Frank, S. Saito, T. Inagami, S.
K. Mitsuyama, Y. Takuwa, T. Sasaki, J. D. Rothstein, H.
Suzuki, H. Nakashima, E. A. Woolfolk, E. D. Motley and S.
Eguchi Signal-Crosstalk between Rho/ROCK and JNK mediates
Migration of Vascular Smooth Muscle Cells stimulated by
Angiotensin. Arterioscler Thromb Vasc Biol.
2005;25:1831-1836.[PubMed]
H. Ohkawara, T. Ishibashi, T. Sakamoto, K. Sugimoto, K.
Nagata, K. Yokoyama, N. Sakamoto, M. Kamioka, I. Matsuoka,
S. Fukuhara, N. Sugimoto, Y. Takuwa and Y. Maruyama.
Thrombin-induced rapid geranylgeranylation of RhoA as an
essential process for RhoA activation in endothelial
cells. J Biol Chem.
2005;18;280(11):10182-10188.[PubMed]
M. Philippova, D. Ivanov, R. Allenspach, Y. Takuwa, P. Erne
and T. Resink. RhoA and Rac mediate endothelial cell
polarication and detachment induced by T-cadherin. FASEB J.
19(6): 588-590, 2005. [PubMed]
T. Senokuchi, T. Matsumura, M. Sakai, M. Yano, T. Taguchi,
K. Sonoda, D. Kukidome, K. Imoto, T. Nishikawa, S.
Kim-Mitsuyama, Y. Takuwa, E. Araki. Statins suppress
oxidized low-density lipoprotein-induced macrophage
proliferation by inactivation of small G protein p38 MAPK
pathway. J. Biol. Chem. 2005, 280(8):
6627-6633.[PubMed]
S. Nagasawa, N. Takuwa, N. Sugimoto, H. Mabuchi and Y.
Takuwa. Inhibition of Rac activation as a mechanism for
negativeregulation of actin cytoskeletal reorganization and
cell motility by cyclic AMP. Biochem J. 385:737-744.
2005[PubMed]
2004
K. Sakurai, L. Cominacini, U. Garbin, A.F. Pasini, N.
Sasaki, Y. Takuwa, T. Masaki, T. Sawamura. Induction of
endothelin-1 production on endothelial cells via
co-operative action between CD40 and lectin-like oxidized
LDL receptor (LOX-1). J Cardiovasc. Pharmacol. 44:
S173-S180, 2004.[PubMed]
K. Sakurai, Y. Matsuo, T. Sudo, Y. Takuwa, S. Kimura, Y.
Kasuya. Role of p38 mitogen-activated protein kinase in
thrombus formation. J Recept Signal Transduct Res. 24(4):
283-296, 2004.[PubMed]
D. Shida, J. Kitayama, H. Yamaguchi, K. Hama, J. Aoki, H.
Arai, H. Yamashita, K. Mori, A. Sako, T. Konishi, T.
Watanabe, T. Sakai, R. Suzuki, H. Ohta, Y. Takuwa and H.
Nagawa. Dual mode regulation of migration by
lysophosphatidic acid in human gastric cancer cells. Exp
Cell Res. 301(2):168-78, 2004.[PubMed]
M. Yamada, Y. Banno, Y. Takuwa, M. Koda, A. Hara and Y.
Nozawa. Overexpression of phospholopase D prevents
actinomycin D induced apoptosis through potentiation of
phosphoinositide 3-kinase signaling pathways in Chinese
hamster ovary cells. Biochem. J., 378(Pt2):649-656 2004.
[PubMed]
S. Usui, N. Sugimoto, N. Takuwa, S. Sakagami, S. Takata, S.
Kaneko and Y. Takuwa. Boold lipid mediator
sphingosine-1-phosphate potently stimulates platelet
derived growth factor-A and -B chain expression through
S1P1-Gi-Ras-MAPK-dependent induction of kruppel-like factor
5. J. Biol. Chem.
279,
12300-12311, 2004. [PubMed]
2003
Y. Takuwa. Regulation of the Rho signaling pathway by
excitatory agonists in vascular smooth muscle. Advances in
Experimental Medicine and Biology.
538:
67-75, 2003. [PubMed]
S. Sakurada, N. Takuwa, N. Sugimoto, Y, Wang, M. Seto, Y.
Sasaki and Y. Takuwa. Ca2+-dependent
activation of Rho and Rho kinase in membrane
depolarization-and receptor stimulation-induced vascular
smoth muscle contraction. Circ. Res.
93:
548-556, 2003. [PubMed]
H. Yamaguchi, J. Kitayama, N. Takuwa, K. Arikawa, I. Inoki,
K. Takehara, H. Nagawa and Y. Takuwa.
Sphingosine-1-phosphate receptor subtype-specific positive
and negative regulation of Rac and hematogenous metastasis
of melanoma cells. Biochem. J.
374:
715-722, 2003. [PubMed]
K. Arikawa, N. Takuwa, H. Yamaguchi, N. Sugimoto, J.
Kitayama, H. Nagawa, K. Takehara and Y. Takuwa.
Ligand-dependent inhibition of B16 melanoma cell migration
and invasion via endogenous S1P2 G protein-coupled receptor
requirement of inhibition of cellular Rac activity. J.
Biol. Chem.
278:
32841-32851, 2003. [PubMed]
J. Xu, F. Wang, A. V. Keymeulen, P. Herzmark, A. Straight,
K. Kelly, Y. Takuwa, N. Sugimoto, T. Mitchison, and H. R.
Bourne. Divergent signals and cytoskeletal assemblies
regulate self-organizing polarity in neutrophils.
Cell
114:
201-214, 2003. [PubMed]
T. Ishibashi, T. Sakamoto, H. Ohkawara, K. Nagata, K.
Sugimoto, S. Sakurada, N. Sugimoto, A. Watanabe, K.
Yokoyama, N. Sakamoto, M. Kurabayashi, Y. Takuwa and Y.
Maruyama. Integral role of RhoA activation in monocyte
adhesion-tringgered tissue factor expression in endothelial
cells. Arteriuscl. Thromb. Vascu. Biol.
23:
681-687, 2003. [PubMed]
D. Shida, J. Kitayama, H. Yamaguchi, Y. Okaji, NH. Tsuno,
T. Watanabe, Y. Takuwa and H. Nagawa. Lysophosphatidic acid
enhances metastatic potential of human colon carcinoma DLD1
cells through LPA1. Cancer Res.
63:
1706-1711, 2003. [PubMed]
N. Sugimoto, N. Takuwa, H. Okamoto, S. Sakurada and Y.
Takuwa. Inhibitory and stimulatory regulation of Rac and
cell motility by the G12/13-Rho-and
the Gi-pathways
integrated downstream of a single G protein coupled
sphingosine-1-phosphate receptor isoform. Mol. Cell.
Biol.
23:
1534-1545, 2003. [PubMed]
K. Ito, E. Shimomura, T. Iwanaga, M. Shiraishi, K. Shido,
J. Nakamura, H. Nagumo, M. Seto, Y. Sasaki and Y. Takuwa.
Essentioal role of rho kinase in the Ca2+
sensitization of prostaglandin F2a-induced
contraction of rabbit aortae. J. Physiol.
546:
823-836, 2003. [PubMed]
H. Ikeda, H. Satoh, M. Yanase, Y. Inoue, T. Tomiya, M.
Arai, K. Tejima, K. Nagashima, H. Maekawa, N. Yahagi, Y.
Tamtomi, S. Sakurada, Y. Takuwa, I. Ogara, S. Kimura and K.
Fujiwara. Antiproliferative action of sphingosine
1-phosphate in rat hepatocytes involves activation of Rho
via Edg-5. Gastroenterology.124:
459-469, 2003. [PubMed]
Y. Banno, Y. Takuwa, M. Yamada, N. Takuwa, K. Ohguchi, A.
Hara and Y. Nozawa. Involvement of phospholipase D in
insulin-like growth factor-I-induced activation of
extracellular signal-regulated kinase, but not
phosphatidylinositol 3-kinase or Akt, in chinese hamster
ovary cells. Biochem. J.
369:
363-368, 2003. [PubMed]
2002
K. Nagata, T. Ishibashi, T. Sakamoto, H. Ohkawara, J.
Shido, K. Yokoyama, K. Sugimoto, S. Sakurada, S. Nakamura,
Y. Maruyama. Rho/Rho-kinase is involved in the synthesis of
tissue factor in human monocytes. Atherosclerosis.
163(1):
39-47, 2002. [PubMed]
T. Ishibashi, K. Nagata, H. Ohkawa, T. Sakamoto, K.
Yokoyama, J. Shido, K. Sugimoto, S. Sakurada, T. Teramoto
and Y. Maruyama. Inhibition of Rho/Rho-kinase signaling
downregulates plasminogen activator inhibitor-1 synthesis
in cultured human monocytes. Biophys. Biochim. Acta.
1590(1-3):
123-130, 2002. [PubMed]
Y. Takuwa, N. Takuwa, N. Sugimoto. The Edg G
protein-coupled receptors for lysophospholipids: Their
signaling properties and biological activities. J.
Biochem.
131:
767-771, 2002. [PubMed]
K. Takami, N. Takuwa, H. Okazaki, M. Kobayashi, T. Ohtoshi,
S. Kawasaki, M. Dohi, K. Yakamoto, T. Nakamura, M. Tanaka,
K. Nakahara, Y. Takuwa and H. Takizawa. Interferon-g inbits
hepatocyte growth factor-stimulated cell proliferation of
human bronchial epithelial cells: upregulation of
p27kip1
cyclin-dependent kinase inhibitor. Am. J. Respir. Cell.
Mol. Biol.
26(2):
231-238, 2002. [PubMed]
Y. Takuwa. Subtype-specific differential regulation of Rho
family G proteins and cell migration by the Edg family
sohingosine-1-phosphate receptors. Biophys. Biochim.
Acta.
1582(1-3):
112-120, 2002. [PubMed]
Y. Ryu, N. Takuwa,
N. Sugimoto
, S. Sakurada, S. Usui, H. Okamoto, O. Matsui and Y.
Takuwa. Sphingosine-1-Phosphate, a Platelet-Derived
Lysophospholipid Mediator, Negatively Regulates Cellular
Rac Activity and Cell Migration in Vascular Smooth Muscle
Cells. Circ Res.
90:
325-332, 2002. [PubMed]
2001
Y. Banno, Y. Takuwa, Y. Akao, H. Okamoto, Y. Osawa, S.
Nakashima, P. G. Suh, Y. Nozawa. Involvement of
phospholipase D in sphingosine 1-phosphate-induced
activation of phosphatidylinositol 3-kinase and Akt in
chinese hamster ovary cells overexpressing EDG3. J. Biol.
Chem.
276:
35622-35628, 2001. [PubMed]
S. Sakurada, H. Okamoto, N. Takuwa, N. Sugimoto and Y.
Takuwa.Rho activation in evcitatory agonist-stimulated
vascular smooth muscle. Am. J. Physiol.(Cell
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281:
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H. Mitui, N. Takuwa, T. Maruyama, H. Maekawa, M. Hrayama,
T. Sawatari, N. Hashimoto, Y. Takuwa and S Kimura. The
MEK1-ERK map kinase pathway and the PI 3-kinase-AKT pathway
independently mediate anti-apoptotic signals in HEPG2 liver
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92:
55-62, 2001. [PubMed]
Y. Takuwa, H. Okamoto, N. Takuwa, K. Gonda, N. Sugimoto and
S. Sakurada.Subtype-Specific, Differential Activities of
the EDG Family Receptors for Sphingosine-1-Phosphate, a
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O. Shido, S. Sakurada, N. Sugimoto, Y. Hiratsuka and Y.
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N. Takuwa and Y. Takuwa. Regulation of cell cycle molecules
by the Ras effector system. Mol. Cell. Endocrinol.
177:
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2000
H. Okamoto, N. Takuwa, T. Yokomizo, N. Sugimoto, S.
Sakurada, H. Shigematsu and Y. Takuwa. Inhibitory
Regulation of Rac Activation, Membrane Ruffling and Cell
Migration by Sphingosine-1-Phosphate Receptor EDG5, but not
EDG1 or EDG3. Mol.Cell.Biol.
20(24):
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H. Ikeda, Y. Yatomi, M. Yanase, H. Satoh, H. Maekawa, I.
Ogara, Y. Ozaki, Y. Takuwa, S. Mochida and K. Fujiwara.
Biological Activities of a Novel Lipid Mediator,
Sphingosine 1-phosphate, in Rat Hepatic Stellate Cells. Am.
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279:
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Kachigian, Y. Takuwa, T. Collins. Mechanisms of
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212(1-2):
183-186, 2000. [PubMed]
H. Nagumo, Y. Sasaki, Y. Ono, H. Okamoto, M. Seto and Y.
Takuwa. Rho kinase inhibitor HA1077 prevents Rho-mediated
myosin phosphatase inhibition in smooth muscle cells. Am.
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278:
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N. Sugimoto, S. Sakurada and O. Shido. Changes in ambient
temperature at the onset of thermoregulatory responses in
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43(4):
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S. Sakurada, O. Shido, N. Sugimoto, Y. Hiratsuka, T. Yoda
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Al. Ivanov , VA. Kulchitsky, N. Sugimoto, CT. Simons and
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tolerance require intact vagal innervation of the liver?
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1999
N. Yukimasa, K Isobe, H Nagai, Y Takuwa, and T Nakai.
Successive occupancy by immediate early transcriptional
factors of the tyrosine hydroxylase gene TRE and CRE sites
in PACAP-stimulatedPC12 pheochromocytoma cells.
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33(6):
475-482, 1999. [PubMed]
J. Deguchi, J. Abe, M. Makuuchi and Y. Takuwa. Inhibitory
effects of trapidil on PDGF signaling in balloon-injurede
rat carotid artery. Life Sci.
65(26):
2791-2799, 1999. [PubMed]
J. Deguchi, M. Makuuchi, T. Nakaoka, T. Collins and Y.
Takuwa. AngiotensinII stimulates platelet-derived growth
factor-B chain expression in newborn rat vascular smooth
muscle cells and neointimal cells through Ras, ERK, and JNK
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85:
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Y. Takuwa. Regulation of smooth muscle myosin phosphatase
and contraction by Rho and Rho kinase. In Molecular
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Kohama and Y. Sasaki. R. G. Landes company. Austin, Texas,
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H. Okamoto, N. Takuwa, Y. Yatomi, K. Gonda, H. Shigematsu
and Y. Takuwa. EDG3 is a functional receptor specific for
sphingosine-1-phosphate and sphingosylphosphorylcholine
with signaling characteristics distinct from EDG1 and
AGR16. Biochem. Biophys. Res. Commun.260(1):
203-208, 1999. [PubMed]
J. Deguchi, T. Nambu, H. Hamada, T. Nakaoka, J. Abe, O.
Sato, T. Miyata, M. Makuuchi, K. Kurokawa and Y. Takuwa.
Targeting endogenous platelet-growth factor B-chain by
adenovirus-mediated gene transfer potently inhibits in vivo
smooth muscle proliferation after arterial injury. Gene
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6(6):
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K. Gonda, H. Okamoto, N. Takuwa, Y. Yatomi, H. Okazaki, T.
Sakurai, S. Kimura, R. Sillard, K. Harii and Y. Takuwa. The
novel sphingosine 1-phosphate receptor AGR16 is coupled via
pertussis toxin-sensitive and -insensitive G-proteins to
multiple signalling pathways. Biochem. J.
337:67-75,
1999. [PubMed]
N. Takuwa, Y. Fukui and Y. Takuwa. Cyclin D1 Expression
Mediated by Phosphatidylinositol 3-Kinase through
mTOR-p70S6K-Independent Signaling in Growth
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N. Sugimoto, C. T. Simons and A. A. Romanovsky. Vagotomy
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N. Sugimoto, S. Sakurada and O. Shido. Selected ambient
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N. Sugimoto, O. Shido, S. Sakurada and T. Nagasaka.
Thermoregulatory responses to acute heat loads in rats
following spontaneous running. Jpn. J. Physiol.
49:
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O. Shido, N. Sugimoto, M. Tanabe and S. Sakurada. Core
temperature and sweating onset in humans acclimated to heat
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N. Sugimoto, O. Shido, F. Furuyama, S. Sakurada and H.
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43:
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1998
K. Hamada, N. Takuwa, K. Yokoyama and Y. Takuwa. Stretch
activates jun N-terminal kinase/stress-activated protein
kinase in vascular smooth muscle cells through mechanisms
involving autocrine ATP stimulation of purinoceptors. J.
Biol. Chem. 273(11); 6334-6340, 1998. [PubMed]
J. Abe, J. Deguchi, K. Hara, Y. Ikari, T. Tamura, M. Ohno,
K. Kurokawa and Y. Takuwa. Tyrosine phosphorylation of
platelet-derived growth factor b- receptors in coronary
artery lesions: implications for vascular remodeling after
directional coronary atherectomy and unstable angina
pectoris. Heart. 79(4); 400-406, 1998. [PubMed]
H. Mitsui, T. Maruyama, S. Kimura and Y. Takuwa. Thrombin
activates two stress-activated protein kinases, c-Jun
N-terminal kinase and p38, in HepG2 cells. Hepatology.
27(5); 1362-1367, 1998. [PubMed]
Y. Takuwa. Regulation of smooth muscle myosin phosphatase
and contraction by Rho and Rho kinase. In Molecular
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Kohama. Springer, Tokyo. 1998. [PubMed]
H. Okamoto, N. Takuwa, K. Gonda, H. Okazaki, K. Chang, Y.
Yatomi, H. Shigematsu and Y. Takuwa. EDG1 is a functional
sphingosine-1-phosphate receptor that is linked via a Gi/o
to multiple signaling pathways including phospholipase C
activation, Ca2+ mobilization, Ras-MAPK activation, and
adenylate cyclase inhibition. J.Biol. Chem. 273;
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N. Sugimoto, O. Shido, S. Sakurada, S. Ito and T. Nagasaka.
Changes in core temperature and thermoeffector thresholds
in exercise-trained rats. Jpn. J. Physiol. 1998 Apr; 48(2):
163-6 [PubMed]
C. T. Simons, V. A. Kulchitsky, N. Sugimoto, L. D. Homer,
M. Szekely and A. A. Romanovsky. Signaling the brain in
systemic inflammation: which vagal branch is involved in
fever genesis? Am. J. Physiol. 1998 Jul; 275(1 Pt 2): R63-8
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A. A. Romanovsky, V. A. Kulchitsky, C. T. Simons and N.
Sugimoto. Methodology of fever research: why are polyphasic
fevers often thought to be biphasic? Am. J. Physiol. 1998
Jul; 275(1 Pt 2): R332-8 [PubMed]
M. F. Van-Oosterhout, F. W. Prinzen, S. Sakurada, R. W.
Glenny and J. R. Hale. Fluorescent microspheres are
superior to radioactive microspheres in chronic blood flow
measurements. Am. J. Physiol. 1998 Jul; 275(1 Pt 2): H110-5
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O. Shido. Can our thermoregulatory system anticipate
temperature exposure? Med. Hypotheses. 1998 Mar; 50(3):
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O. Shido, S. Sakurada, N. Sugimoto, F. Furuyama and T.
Nagasaka. Thermoeffector thresholds and preferred ambient
temperatures of the FOK rat. Am. J. Physiol. 274(3 Pt 2):
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A. A. Romanovsky, C. T. Simons, V. A. Kulchitsky, N.
Sugimoto and M. Szekely. Vagus nerve in fever. Recent
developments. Ann. N. Y. Acad. Sci. 856:298-299, 1998.
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Sakurada. S and J. R. Hales. A role for gastrointestinal
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fitness. J. Appl. Physiol. 1998 Jan; 84(1): 207-14 [PubMed]
H. Mitsui, N. Takuwa, K. Kurokawa, J. H. Exton and Y.
Takuwa. Dependence of activated Ga12-induced G1 to S phase
cell cycle progression on both Ras/MAPK and Ras/Rac1/JNK
cascades in NIH3T3 fibroblasts. J. Bio. Chem. 272 (8)
4904-4910, 1997. [PubMed]
1997
J. Abe, J. Deguchi, T. Matsumoto, N. Takuwa, M. Noda, M.
Ohno, M. Makuuchi, K. Kurokawa, and Y. Takuwa. Stimulated
activation of platelet-derived growth factor receptor in
vivo in balloon-injured arteries - a link between
angiotensin II and intimal thickening. Circulation 96(6):
1906-1913, 1997. [PubMed]
T. Yokomizo, T. Izumi, K. Chang, Y. Takuwa and T. Shimizu.
A G-protein coupled receptor for leukotriene B4 that
mediates chemotaxis. Nature 387: 620-624, 1997. [PubMed]
M. Hirakata, S. Kaname, U. Chung, N. Joki, Y. Hori, M.
Noda, Y. Takuwa, T. Okazaki, T. Fujita, T. Katoh, and K.
Kurokawa. Tyrosine kinase dependent expression of TGF-
induced by stretch in mesangial cells. Kid. International
51: 1028-1036, 1997. [PubMed]
N. Takuwa and Y. Takuwa. Ras activity late in G1 phase
required for p27Kip1 downregulation, passage through the
restriction point, and entry into S phase in growth
factor-stimulated NIH3T3 fibroblasts. Mol. Cell. Biol.
17(9): 5348-5358, 1997. [PubMed]
M. Noda, T. Katoh, K. Kurokawa and Y. Takuwa. Increased
expression of parathroid hormone-related peptide gene in
blood vessels of spontaneously hypertensive rats.
Hypertension 30 (5): 1284-1288, 1997. [PubMed]
Y. Takuwa, K. Hamada, J. Abe, K. Chang, J. Deguchi and N.
Takuwa. Functional roles of locally produced vasoactive
substances in vascular responses to mechanical stress and
injury. CVD Grand Round Series Vol. 3 (Ed. T. Asano, T.
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T. Nakaoka, K. Gonda, T. Ogita, Y. Otawara-Hamamoto, F.
Okabe, Y. Kira, K. Harii, K. Miyazono, Y. Takuwa and T.
Fujita. Inhibition of rat vascular smooth muscle
proliferation in vitro and in vivo by bone morphogenetic
protein-2. J. Clin. Invest. 100( 11); 2824-2832, 1997.
[PubMed]
A. A. Romanovsky, V. A. Kulchitsky, C. T. Simons, N.
Sugimoto and M. Szekely. Cold defense mechanisms in
vagotomized rats. Am. J. Physiol. 273(2 Pt 2): R784-789,
1997. [PubMed]
A. A. Romanovsky, V. A. Kulchitsky, C. T. Simons, N.
Sugimoto and M. Szekely. Febrile responsiveness of
vagotomized rats is suppressed even in the absence of
malnutrition. Am. J. Physiol. 273(2 Pt 2): R777-783, 1997.
[PubMed]
N. Sugimoto, O. Shido, S. Sakurada and T. Nagasaka.
Lipopolysaccharide-induced fever in rats prolonged by a
needle prick. Jpn. J. Physiol. 47(2): 199-204, 1997.
[PubMed]
O. Shido, N. Sugimoto, S. Sakurada, Y. Kaneko and T.
Nagasaka. Body core temperature of rats subjected to daily
exercise limited to a fixed time. Int. J. Biometeorol.
40(3): 135-140, 1997. [PubMed]
A. A. Romanovsky, O. Shido, S. Sakurada, N. Sugimoto and T.
Nagasaka. Endotoxin shock-associated hypothermia. How and
why does it occur? Ann. N. Y. Acad. Sci. 15; 813: 733-737,
1997. [PubMed]
O. Shido, S. Sakurada, N. Sugimoto, F. Furuyama, H. Nishino
and T. Nagasaka. Preferred ambient temperature and
threshold temperatures for thermoregulation in the FOK rat.
Ann. N. Y. Acad. Sci. 15; 813: 652-653, 1997. [PubMed]
N. Sugimoto, O. Shido, F. Furuyama, H. Nishino and T.
Nagasaka. Heat loss responses to acute heat loads in the
FOK rat. Ann. N. Y. Acad. Sci. 15; 813: 644-645, 1997.
[PubMed]
J. R. Hales and S. Sakurada. Role of endotoxins in the
enhanced heat tolerance of fit subjects. Ann. N. Y. Acad.
Sci. 15; 813: 545-547, 1997. [PubMed]
N. Sugimoto, O. Shido, S. Sakurada, A. Hirai, Y. Kaneko and
T. Nagasaka. How does heat acclimation after the preferred
ambient temperatures of rats? In: Thermal Physiology 1997.
Ed. By B. Nielsen Johannsen and R. Nielsen. Denmark: The
August Krogh Institute. 91-94, 1997 [PubMed]
O. Shido, N. Sugimoto, S. Sakurada and T. Nagasaka. Body
core temperature and threshold for sweating of humans after
exposure to heat given daily at a fixed time. In: Thermal
Physiology 1997. Ed. By B. Nielsen Johannsen and R.
Nielsen. Denmark: The August Krogh Institute. 95-98, 1997.
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V. A. Kulchisky, A. A. Romanovsky, C.T. Simons, N. Sugimoto
and M. Szekely. The brown fat in the thermoregulatory
response of vagotomized rats to lipopolysaccharide. In:
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Gournie. Minsk: Institute of Physiology, National Academy
of Sciences. 141-145, 1997. [PubMed]
1996
K. Hamada, N. Takuwa, W. Zhou, M. Kumada and Y. Takuwa.
Protein kinase C inhibits the CAK-CDK2 cyclin-dependent
kinase cascade and G1/S Cell cycle progression in human
diploid fibroblasts. Biochem.Biophys.Acta. 1310: 149-156,
1996. [PubMed]
K. Isobe, N. Yukimasa, T. Nakai and Yoh Takuwa. Pituitary
adenylate cyclase-activating polypeptide induces gene
expression of the catecholamine sysnthesizing enzymes,
tyrosine hydrozylase and dopamine beta-hydroxylase, through
3', 5'-cyclic adenosine monophosphate- and protein kinase
C-dependent mechanisms in cultured porcine adrenal
medullary chromaffin cells. Neuropeptides. 30: 167-175,
1996. [PubMed]
M. Noda, T. Yoh, T. Katoh and K. Kurokawa. Mechanical force
regulation of vascular parathyroid hormon-related peptide
expression. Kidney International 49: S154-S155, 1996.
[PubMed]
Y. Takuwa. Regulation of vascular smooth muscle
contraction: Ca2+, protein kinase C and myosin light chain
phosphatase. Japan. Heart J. 37: 793-813, 1996. [PubMed]
N. Takuwa and Y. Takuwa. Signal transduction of the cell
cycle regulation. its temporo-spacial architecture. Japan.
J. Physiol. 46(6) 431-449, 1996 [PubMed]
K. Isobe, N. Yukimasa, T. Nakai and Yoh Takuwa. Pituitary
adenylate cyclase-activating polypeptide induces gene
expression of the catecholamine sysnthesizing enzymes,
tyrosine hydrozylase and dopamine beta-hydroxylase in
cultured porcine adrenal medullary chromaffin cells. Ann.
N.Y. Acad .Sci. 805: 464-469, 1996. [PubMed]
N. Sugimoto, O. Shido, S. Sakurada and T. Nagasaka.
Day-night variations of behavioral and autonomic
thermoregulatory responses to lipopolysaccharide in rats.
Jpn. J. Physiol. 1996 Dec; 46(6): 451-6 [PubMed]
A. A. Romanovsky, O. Shido, S. Sakurada, N. Sugimoto and T.
Nagasaka. Endotoxin shock: thermoregulatory mechanisms. Am.
J. Physiol. 1996 Apr; 270(4 Pt 2): R693-703 [PubMed]
1995
N. Takuwa, W. Zhou, amd Y. Takuwa. Calcium, calmodulin and
cell cycle progression. Cellular Signalling 7: 93-104,
1995. [PubMed]
N. Takuwa, W. Zhou and Y. Takuwa. Involvement of intact
inositol-1, 4, 5-trisphosphate-sensitive Ca2+ stores in
cell cycle progression at the G1/S boundary in
serum-stimulated human fibroblasts. FEBS Letters 360:
173-176, 1995. [PubMed]
M. Noda, C. Yasuda-Fukazawa, K. Morishi, T. Kato, T. Okuda,
K. Kurokawa and Y. Takuwa. Involvement of rho in
GTPgS-induced enhancement of phosphorylation of 20 kDa
myosin light chain in vascular smooth muscle
cells:Inhibition of phosphatase activity. FEBS Letters 367:
246-250, 1995. [PubMed]
G. Whitney, D. Throckmorton, C. Isales, Y. Takuwa, J. Yeh,
H. Rasmussen and C. Brophy. Kinase activation and smooth
muscle contraction in the presence and absence of calcium.
J. Vascu. Surgery. 22: 37-44, 1995. [PubMed]
M. Noda, Y. Takuwa, T. Katoh and K. Kurokawa.
Stretch-induced parathyroid hormone-related peptide gene
expression: implication in the regulation of myogenic tone.
Curr. Opin. Nephrol. Hypertension 4: 383-387, 1995.
[PubMed]
K. Chang, K. Hanaoka, M. Kumada and Y. Takuwa. Molecular
cloning and functional analysis of a novel P2 nucleotide
receptor. J. Bio. Chem. 270: 26152-26158, 1995. [PubMed]
Y. Takuwa, M. Noda, C. Yasuda, M. Kumada and K. Kurokawa.
Regulation of Ca2+-dependent phosphorylation of 20-kDa
myosin light chain by the small molecular weight G protein
rho p21 in vascular smooth muscle cells. In Nakano,T. and
Hartshorne, D. J. (eds.), Regulation of the contractile
cycle in smooth muscle. Springer. 103-110, 1995. [PubMed]
T. Kiyohara, S. Miyata, T. Nakamura, O. Shido, T. Nakashima
and M. Shibata. Differences in Fos expression in the rat
brains between cold and warm ambient exposures. Brain. Res.
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S. Miyata, M. Ishiyama, O. Shido, T. Nakashima, M. Shibata
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with cold acclimation of rats using Fos
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O. Shido, S. Sakurada, N. Sugimoto and T. Nagasaka. Shifts
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Physiol. Lond. 1995 Mar 1; 483 ( Pt 2): 491-7. [PubMed]
N. Sugimoto, O. Shido and S. Sakurada. Thermoregulatory
responses of rats acclimated to heat given daily at a fixed
time. J. Appl. Physiol. 1995 May; 78(5): 1720-4. [PubMed]
S. Sakurada, O. Shido, K. Yamamoto, N. Sugimoto, T.
Kobayashi and T. Nagasaka. Effect of digital nerve blockade
on heat-induced vasoconstriction in the human finger. J.
Appl. Physiol. 1995 Feb; 78(2): 746-9. [PubMed]
1994
J. Abe, W. Zhou, J. Taguchi, N. Takuwa, K. Miki, H.
Okazaki, K. Kurokawa, M. Kumada and Y. Takuwa. Suppression
of neointimal smooth muscle cell accumulation in vivo by
antisense cdc2 and cdk2 oligonucleotides in rat carotid
artery. Biochem. Biophys. Res. Commun. 198: 16-24, 1994.
[PubMed]
W. Zhou, N. Takuwa, M. Kumada and Y. Takuwa. E2F1, B-myb
and selective members of cyclin/CDK subunits are targets
for protein kinase C-mediated bimodal growth regulation in
vascular endothelial cells. Biochem. Biophys. Res. Commun.
199: 191-198, 1994. [PubMed]
N. Ishizaka, H. Okazaki, K. Kurokawa, M. Kumada and Y.
Takuwa. Molecular cloning of a novel putative G
protein-coupled receptor from rat aortic smooth muscle.
Downregulation of the mRNA level by the cyclic AMP
messenger pathway. Biochim. Biophys. Acta 1218: 173-180,
1994. [PubMed]
J. Abe, W. Zhou, N. Takuwa, J. Taguchi, K. Kurokawa, M.
Kumada and Y. Takuwa. A fumagillin derivative angiogenesis
inhibitor, AGM-1470, inhibits activation of
cyclin-dependent kinases and phosphorylation of
retinoblastoma gene product but not protein tyrosyl
phosphorylation or protooncogene expression in vascular
endothelial cells. Cancer Research 54: 3407-3712, 1994.
[PubMed]
M. Noda, T. Katoh, N. Takuwa, M. Kumada, K. Kurokawa and Y.
Takuwa. Synergistic stimulation of parathyroid
hormone-related peptide gene expression by mechanical
stretch and angiotensin II in rat aortic smooth muscle
cells. J. Biol. Chem. 269: 17911-17917, 1994. [PubMed]
1993
N. Takuwa, W. Zhou, M. Kumada and Y. Takuwa. Ca2+-
dependent stimulation of retinoblastoma gene product
phosphorylation and p34cdc2 kinase activation in
serum-stimulated human fibroblasts. J. Biol. Chem. 268:
138-145, 1993. [PubMed]
T. Asano, T. Mastui, T. Watanabe, T. Koide and Y. Takuwa.
The pathogenetic mechanism underlying cerebral vasospasm.
Cellular membrane a key to disease processes. (T. Ohnishi
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H. Okazaki, N. Ishizaka, T. Sakurai, K. Kurokawa, K. Goto,
M. Kumada and Y. Takuwa. Molecular cloning of a novel
putative G protein-coupled receptor expressed in the
cardiovascular system. Biochem. Biophys. Res. Commun. 190:
1104-1109, 1993. [PubMed]
K. Isobe, T. Nakai and Y. Takuwa. Ca2+- dependent
stimulatory effect of pituitary adenylate
cyclase-activating polypeptide on catecholamine secretion
from cultured pocine adrenal medullary chromaffin cells.
Endocrinology 132: 1757-1765, 1993. [PubMed]
Y. Takuwa, T. Matsui, Y. Abe, T. Nagafuji, K. Yamashita and
T. Asano. Alterations in protein kinase C activity and
membrane lipid metabolism in cerebral vasospasm after
subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 13:
409-415, 1993. [PubMed]
Y. Takuwa. Endothelin in vascular and endocrine systems:
biological activities and its mechanisms of action.
Endocrine J. 40: 489-506, 1993. [PubMed]
W. Zhou, N. Takuwa, M. Kumada, Y. Takuwa. Protein kinase
C-mediated bidirectional regulation of DNA synthesis, RB
protein phosphorylation and cyclin-dependent kinases in
human vascular endothelial cells. J. Biol. Chem. 268:
23041-23048, 1993. [PubMed]
J. Taguchi, J. Abe, H. Okazaki, Y. Takuwa and K. Kurokawa.
L-arginine inhibits neointimal formation following balloon
injury. Life Sciences 53: PL387-392, 1993. [PubMed]
J. Taguchi, J. Abe, H. Okazaki, M. Ochiai, M. Ohno, Y.
Takuwa and K. Kurokawa. Angiotensin converting enzyme
inhibitors or dup753 prevent neointimal formation following
balloon injury with single topical or multiple systemic
applocation. Biochem. Biophys. Res. Commun. 196: 969-974,
1993. [PubMed]
1992
N. Takuwa, W. Zhou, M. Kumada and Y. Takuwa.
Ca2+/calmodulin is involved in growth factor-induced
retinoblastoma gene product phosphorylation in human
vascular endothelial cells. FEBS Letters 306: 173-175,
1992. [PubMed]
T. Sakurai, H. Morimoto, Y. Kasuya, Y. Takuwa, H. Nakauchi,
T. Masaki and K. Goto. Level of ETB receptor mRNA is
down-regulated by endothelins through decreasing the
intracellular stability of mRNA molecules. Biochem.
Biophys. Res. Commun. 186: 342-347, 1992. [PubMed]
Y. Kasuya, Y. Takuwa, M. Yanagisawa, T. Masaki and K. Goto.
A pertussis toxin-sensitive mechanism of endothelin action
in porcine coronary artery smooth muscle. Br. J. Pharmacol.
107: 456-462, 1992. [PubMed]
N. Takuwa, W. Zhou, M. Kumada and Y. Takuwa. Activators of
protein kinase C induce p34cdc2 histone H1 kinase
stimulation in Swiss 3T3 fibroblasts. Biochem. Biophys.
Res. Commun. 188: 1084-1089, 1992. [PubMed]
K. Onozaki, K. Kato, S. Inui, Y. Takuwa and Y. Akiyama.
Cyclic AMP mimics IL-1 action on augmenting the
differentiation of a mouse myeloid leukemic cell line (M1).
J. Parmacobio-Dyn. 15: 491-500, 1992. [PubMed]
T. Yamaoka, T. Kudo, Y. Takuwa, Y. Kawakami, M. Itakura and
K. Yamashita. Hereditary adrenocoritical unresponsiveness
to adrenocoritcopin with a postreceptor defect. J. Clin.
Endocrin. Meta. 75: 270-274, 1992. [PubMed]
1991
Y. Takuwa, C. Ohse, E. A. Wang, J. M. Wozney and K.
Yamashita. Bone morphogenetic protein-2 stimulates alkaline
phosphatase activity and collagen synthesis in cultured
osteoblastic cells, MC3T3-E1. Biochem. Biophys. Res.
Commun. 174: 96-101, 1991. [PubMed]
N. Takuwa, A. Iwamoto, M. Kumada, K. Yamashita and Y.
Takuwa. Role of Ca2+ influx in bombesin-induced mitogenesis
in Swiss 3T3 fibroblasts. J. Biol. Chem. 266: 1403-1409,
1991. [PubMed]
T. Masaki, M. Yanagisawa, K. Goto, S. Kimura and Y. Takuwa.
Cardiovascular significance of endothelin. Cardiovascular
significance of endothelium-derived vasoactive factors. (G.
M. Rubanyi ed. Future Publishing Co.) PP. 65-81, 1991.
[PubMed]
T. Matsui, Y. Takuwa, H. Joshita, K. Yamashita and T.
Asano. Possible role of protein kinase C-dependent smooth
muscle contraction in the pathogenesis of chronic cerebral
vasospasm. J. Cereb. Blood Flow Metab. 11: 143-149, 1991.
[PubMed]
Y. Takuwa, T. Masaki and K. Yamashita. The mechanisms of
endothelin action in vascular smooth muscle cells.
Contributions Nephrol. 90: 99-104, 1991. [PubMed]
A. Sakamoto, M. Yanagisawa, T. Sakurai, Y. Takuwa, M.
Yanagisawa and T. Masaki. Cloning and functional expression
of human cDNA for the ETB endothelin receptor. Biochem.
Biophys. Res. Commun. 178: 656-663, 1991. [PubMed]
N. Takuwa, M. Kumada, K. Yamashita and Y. Takuwa.
Mechanisms of bombesin-induced arachidonate mobilization in
Swiss 3T3 fibroblasts. J. Biol. Chem. 266: 14237-14243,
1991. [PubMed]
T. Matsui, M. Sugawa, H. Joshita, Y. Takuwa and T. Asano.
Activation of the protein kinase C-mediated contractile
system in canine basilar artery undergoing chronic
vasospasm. Stroke 22: 1183-1187, 1991. [PubMed]
Y. Abe, Y. Kasuya, M. Kudo, K. Yamashita, K. Goto, T.
Masaki and Y. Takuwa. Endothelin-1-induced phosphorylation
of 20kDa myosin light chain and caldesmon in porcine
coronary artery smooth muscle. Japan J. Pharmacol. 57:
431-435, 1991. [PubMed]
1990
Y. Takuwa, M. Yanagisawa, N. Takuwa and T. Masaki.
Endothelin, its diverse biological activities and
mechanisms of action. Progress Growth Factor Res. 1:
195-206, 1990. [PubMed]
Y. Takuwa, Y. Kasuya, N. Takuwa, M. Kudo, M. Yanagisawa, K.
Goto, T. Masaki and K. Yamashita. Endothelin receptor is
coupled to phospholipase C via a guanine nucleotide binding
regulatory protein which is distinct from pertussis toxin
substrates. J. Clin. Invest. 85: 653-658, 1990. [PubMed]
T. Matsui, Y. Takuwa, K. Yamashita and T. Asano. The
protein kinase C-dependent contractile system participates
in the occurrence of chronic vasospasm. Pharmacology of
Cerebral Ischemia (J. Krieglstein, H. Oberpichler eds.
Wissenschaftliche Verlagsgesellschaft) PP. 145-149, 1990.
[PubMed]
Y. Takuwa and H. Rasmussen. Role of Ca2+ and protein kinase
C in the smooth muscle contraction. Proceedings of the IVth
International Conference on Cerebral Vasospasm (K. Sano, K.
Takakura et al. eds. University of Tokyo Press) PP. 59-64,
1990.
T. Sakurai, M. Yanagisawa, Y. Takuwa, H. Miyazaki, S.
Kimura, K. Goto and T. Masaki. Cloning of a cDNA encoding a
non-isopeptide-selective subtype of the endothelin
receptor. Nature 348: 732-735, 1990. [PubMed]
T. Masaki, M. Yanagisawa, S. Kimura, Y. Takuwa and K. Goto.
Effect of endothelin on cardiovascular system. Jpn. Heart
J. 31: 517-518, 1990. [PubMed]
H. Rasmussen, H. Haller, Y. Takuwa, G. Kelley and S. Park.
Messenger Ca2+, protein kinase C and smooth muscle
contraction. Frontiers in Smooth Muscle Research PP.
89-106, 1990. [PubMed]
S. Nakamura, N. Kuzuya, Y. Koide, M. Matsumura, Y.
Watanabe, H. Tomizawa, Y. Murayama, Y. Okuda, Y. Takuwa, M.
Itakura, K. Kawai, E. Ueno, E. Akaogi, K. Fukao and K.
Yamashita. Successful Treatment of a metastatic
hormone-producing adrenal cancer by a combination of
mitotane, tegafur and surgical resection. Endocrinol. Jpn.
37: 753-762, 1990. [PubMed]
Y. Takuwa, T. Masaki and K. Yamashita. The effects of the
endothelin family peptides on cultured osteoblastic cells
from rat calvariae. Biochem. Biophys. Res. Commun. 170:
998-1005, 1990. [PubMed]
T. Masaki, M. Yanagisawa, Y. Takuwa, K. Kasuya, S. Kimura
and K. Goto. Cellular mechanism of vasoconstriction induced
by endothelin. The Biology and Medicine of Signal
Transduction. (Y. Nishizuka ed. Raven Press) PP. 425-428,
1990. [PubMed]
N. Takuwa, Y. Takuwa, Y. Ohue, H. Mukai, K. Endoh, K.
Yamashita, M. Kumada and E. Munekata. Stimulation of
calcium mobilization but not proliferation by bombesin and
tachykinin neuropeptides in human small cell lung cancer
cells. Cancer Res. 50: 240-244, 1990. [PubMed]
1989
Y. Takeuchi, T. Matsumoto, Y. Takuwa, Y. Hoshino, T.
Kurokawa, N. Shibuya and E. Ogata. High incidence of
obesity and elevated serum immunoreactive insulin level in
patients with paravertebral ligamentous ossification. J.
Bone Mineral Metab. 7: 17-21, 1989. [PubMed]
M. Yanagisawa, A. Inoue, Y. Takuwa, Y. Mitsui, M. Kobayashi
and T. Masaki. The human preproendothelin-1 gene: possible
regulation by endothelial phosphoinositide turnover
signaling. J. Cardiovascuel. Pharmacol. 13(Suppl. 5):
S13-S17, 1989. [PubMed]
A. Inoue, M. Yanagisawa, Y. Takuwa, Y. Mitsui, M. Kobayashi
and T. Masaki. The human preproendothelin-1 gene. Complete
nucleotide sequence and regulation of expression. J. Biol.
Chem. 264: 14954-14959, 1989. [PubMed]
K. Goto, Y. Kasuya, N. Matsui, Y. Takuwa, H. Kurihara, T.
Ishikawa, S. Kimura, M. Yanagisawa and T. Masaki.
Endothelin activates the
dihydropyridine-sensitive,voltage-dependent Ca2+ channel in
vascular smooth muscle. Proc. Natl. Acad. Sci. USA. 86:
3915-3918, 1989. [PubMed]
Y. Kasuya, Y. Takuwa, M. Yanagisawa, S. Kimura, K. Goto and
T. Masaki. Endothelin-1 induces vasoconstriction through
two functionally distinct pathways in porcine coronary
artery: contribution of phosphoinositide turnover. Biochem.
Biophys. Res. Commun. 161: 1049-1055, 1989. [PubMed]
N. Takuwa, Y. Takuwa, M. Yanagisawa, K. Yamashita and T.
Masaki. A novel vasoactive peptide endothelin stimulates
mitogenesis through inositol lipid turnover in Swiss 3T3
fibroblasts. J. Biol. Chem. 264: 7856-7861, 1989. [PubMed]
Y. Takuwa, Y. Ohue and K. Yamashita. Endothelin-1 activates
phospholipase C and mobilizes Ca2+ from extra- and
intracellular pools in osteoblastic cells. Am. J. Physiol.
257: E797-E803, 1989. [PubMed]
N. Takuwa, M. Ganz, Y. Takuwa, R. B. Sterzel and H.
Rasmussen. Studies of the mitogenic effect of serotonin in
rat renal mesangial cells. Am. J. Physiol. 257: F431-F439,
1989. [PubMed]
1988
Y. Takuwa, N. Takuwa and H. Rasmussen. The effects of
isoproterenol on intracellular Ca2+ concentration in bovine
tracheal smooth muscle. J. Biol. Chem. 263: 762-768, 1988.
[PubMed]
N. Takuwa, Y. Takuwa and H. Rasmussen. Stimulation of
mitogenesis and glucose transport by 1-monooleoylglycerol
in Swiss 3T3 fibroblasts. J. Biol. Chem. 263: 9738-9745,
1988. [PubMed]
M. Yamamoto, Y. Takuwa, S. Masiko and E. Ogata. Effects of
endogenous and exogenous parathyroid hormone on tubular
reabsorption of calcium in pseudohypoparathyroidism. J.
Clin. Endocrinol. Metab. 66(3) 618-625, 1988. [PubMed]
H. Rasmussen, C. Isales, Y. Takuwa, N. Takuwa, P. Barrett
and W. Zawalich. The cellular basis for short-term memory
in endocrine systems. Cellular mechanisms of conditioning
and behavioral plasticity (D. Woody, D. L. Alkon and J. L.
McGaugh ed. Plenum Publishing Corporation) PP. 3-10, 1988.
[PubMed]
S. Paglin, Y. Takuwa, K. E. Kamm, J. T. Stull, H. Garvas
and H. Rasmussen. Atrial natriuretic peptide inhibits the
agonist-induced increase in extent of myosin light chain
phosphorylation in aortic smooth muscle. J. Biol. Chem.
263: 13117-13120, 1988. [PubMed]
Y. Takuwa, G. Kelley, N. Takuwa and H. Rasmussen. Protein
phosphorylation changes in bovine carotid artery smooth
muscle during contraction and relaxation. Mol. Cell.
Endocrinol. 60: 71-86, 1988. [PubMed]
1987
Y. Takeuchi, T. Matsumoto,Y. Takuwa and E. Ogata. Effect of
salmon calcitonin on malignancy-associated hypercalcemia.
J. Bone Mineral Metab. 4: 1-8, 1987. [PubMed]
H. Rasmussen, P. Barrett, Y. Takuwa and W. Apfeldorf.
Calcium in the regulation of aldosterone secretion and
vascular smooth muscle contraction. Hypertension. 10(Suppl
I): I-23-I-26, 1987. [PubMed]
N. Takuwa, Y. Takuwa and H. Rasmussen. The effects of
bombesin on phosphoinositide and calcium metabolism in
Swiss 3T3 cells. J. Biol. Chem. 262(1): 182-188, 1987.
[PubMed]
W. Zawalich, N. Takuwa, Y. Takuwa, V. Diaz and H.
Rasmussen. Interactions of cholecystokinin and glucose in
rat pancreatic islets. Diabetes 36(4): 426-433, 1987.
[PubMed]
N. Takuwa, Y. Takuwa and H. Rasmussen. A tumour promotor,
12-0-tetradecanoylphorbol 13-acetate, increases cellular
1,2-diacylglycerol content through a mechanism other than
phosphoinositide hydrolysis in Swiss 3T3 fibroblasts.
Biochem. J. 243(3) 647-653, 1987. [PubMed]
H. Rasmussen, S. Park, Y. Takuwa, N. Takuwa, W. Apfeldorf
and P. Barrett. A temporo-spatial model of Ca2+ messenger
action. Calcium regulation and bone metabolism: basic and
clinical aspects (D. V. Chon, T. J. Martin, P. J. Meunier
ed. Elsevier Science Publishers B. V. ) 9: 159-166, 1987.
[PubMed]
H. Rasmussen, P. Barrett, W. Apfeldorf, Y. Takuwa, N.
Takuwa, J. Smallwood,C. Isales, W. Bollag and P. Stein.
Multiplicity of Ca2+ signal transduction pathways.
Calcium-dependent processes in the liver. (C. Heilmann ed.
MTP Press Limited) PP. 9-29, 1987. [PubMed]
Y. Takuwa and H. Rasmussen. Measurement of cytoplasmic free
Ca2+ in rabbit aorta using the photoprotein, aequorin.
Effect of atrial natriuretic peptide on agonist-induced
Ca2+ signal generation. J. Clin. Invest. 80: 248-257, 1987.
[PubMed]
Y. Takuwa, N. Takuwa and H. Rasmussen. Measurement of
cytoplasmic free Ca2+ concentration in bovine tracheal
smooth muscle using the photoprotein, aequorin. Am. J.
Physiol. 253: C817-C827, 1987. [PubMed]
H. Rasmussen, Y. Takuwa and S. Park. Protein kinase C in
the regulation of the smooth muscle contraction. FASEB J.
1: 177-185, 1987. [PubMed]
1986
Y. Takuwa, M. Yamamoto, T. Matsumoto, K. Hata and E. Ogata.
Hyperphosphatemia after surgical correction of
hypercortisolism in patients with Cushing's syndrome.
Mineral Electrol. Metab. 12(2): 119-124, 1986. [PubMed]
Y. Takuwa and E. Ogata. Regulation of sodium-coupled
phosphate transport by extracellular phosphate in cultured
kidney cells (JTC-12). Clin. Sci. 71(2): 307-312, 1986.
[PubMed]
Y. Takuwa, N. Takuwa and H. Rasmussen. Carbachol induces a
rapid and sustained hydrolysis of polyphosphoinositide in
bovine tracheal smooth muscle. Measurement of the mass of
polyphosphoinositide, 1,2-diacylglycerol and phosphatidic
acid. J. Biol. Chem. 261(3): 14670-14675, 1986.
H. Rasmussen, W. Apfeldorf, P. Barret, N. Takuwa, W
Zawalich, D. Kreutter, S. Park, and Y. Takuwa. Inositol
lipids: integration of cellular signalling systems. In:
Phosphoinositides and Receptor Mechanisms (Alan R. Liss,
Inc.) PP. 109-147, 1986.
1985
Y. Takuwa and E. Ogata. Characterization of Na+-dependent
phosphate uptake in cultured kidney cells (JTC-12) from
monkey. Biochem. J. 230(3): 715-721, 1985.
Y. Takuwa and E. Ogata. Differentiated properties
characteristic of renal proximal epithelium in a cell line
derived from a normal monkey kidney (JTC-12). In Vitro Cell
Dev. Biol. 21(8): 445-449, 1985.
Y. Takuwa T. Matsumoto, T. Kurokawa, M. Iizuka, Y. Hoshino,
K. Hata and E. Ogata. Calcium metabolism in paravertebral
ligamentous ossification. Acta Endocrinol. 109(2): 428-432,
1985.
N. Yamashita, Y. Takuwa and E. Ogata. Growth
hormone-releasing factor reduces voltage-gated Ca2+ channel
current in rat GH3 cells. J. Membr. Biol. 87(3): 241-247,
1985.
1984
T. Matsumoto, Y. Takuwa, T. Okazaki, Y. Hoshino, M. Iizuka,
T. Kurokawa, K. Hata and E. Ogata. Association of
paravertebral ligamentous ossification with
hypoparathyroidism. Endocrine control of bone and calcium
metabolism. (In D. V. Cohn, T. Fujita, J. T. Potts Jr, R.
V. Talmage) Elsevier Scienc B.V., 26-31, 1984.
T. Okazaki, Y. Takuwa, M. Yamamoto, T. Igarashi,T. Kurokawa
and E. Ogata. Ossification of the paravertebral ligaments:
A frequent complication of hypoparathyroidism. Metabolism.
33(8): 710-713, 1984.